Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Necrosis
ADR ID BADD_A02982
ADR Hierarchy
08      General disorders and administration site conditions
08.03      Tissue disorders NEC
08.03.03      Necrosis NEC
08.03.03.001      Necrosis
24      Vascular disorders
24.04      Arteriosclerosis, stenosis, vascular insufficiency and necrosis
24.04.02      Non-site specific necrosis and vascular insufficiency NEC
24.04.02.006      Necrosis
Description The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process. [MeSH]
MedDRA Code 10028851
MeSH ID D009336
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Necrosis | Necrosis NOS | Coagulation necrosis | Colliquation necrosis | Liquefactive necrosis | Necroses
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Angiopoietin-related protein 4Q9BY76T98635
Sodium/potassium-transporting ATPase subunit alpha-1P05023T40800
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00858Everolimus0.001460%
BADD_D00871Felbamate--
BADD_D00879Fentanyl--
BADD_D00898Finasteride0.000321%
BADD_D00931Fluorouracil--
BADD_D00932Fluoxetine--
BADD_D00974Fragmin--
BADD_D00983Gadobenate dimeglumine--
BADD_D00989Gadolinium--
BADD_D01009Gemcitabine0.001865%
BADD_D01059Heparan sulfate--
BADD_D01060Heparin0.016698%
BADD_D01086Hydrocortisone--
BADD_D01119Ibrutinib0.001332%
BADD_D01127Idarubicin--
BADD_D01133Ifosfamide--
BADD_D01136Imatinib0.001332%
BADD_D01181Iopamidol--
BADD_D01182Iopromide--
BADD_D01184Iothalamic acid--
BADD_D01186Ioversol--
BADD_D01188Ioxaglic acid--
BADD_D01203Isoflurane--
BADD_D01231Ketoprofen--
BADD_D01243Lamotrigine0.000258%
BADD_D01253Lenalidomide--
BADD_D01255Lercanidipine--
BADD_D01281Levonorgestrel0.004169%
BADD_D01366Medroxyprogesterone acetate--
BADD_D01378Memantine--
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